Drug products · Labels read 2026-08-16
Every FDA-approved estradiol brand, and which ones still exist
Search Estrace and you get dosing advice for a tablet the FDA's own record lists as discontinued at every strength. The reason that is easy to miss: the fact is not on the label. It sits on a different FDA database, the one that tracks what is being shipped rather than what was approved.
19 FDA-approved products carry estradiol or an estradiol ester as their only hormone and a name a patient can look up, and 5 more pair estradiol with a progestogen. They span 6 delivery forms, from a patch applied once a week to a ring worn for three months. Same molecule, different products: the dosing schedules differ, and so do the conditions each label is approved to treat. Estrace tablets are Discontinued at all three strengths on the FDA application record, and only Estrace Cream is still marketed. Another 5 products here carry a strength the FDA record lists as Discontinued, and on 2 of those the current label still prints it. Below: every one of them, its labelled strengths, how often the label says to use it, and which of these forms the 13 platforms we price-verify actually dispense.
By Iacob Pastina. Every strength, dosing interval and indication below was read on 2026-08-16from the product's structured label on DailyMed. Every marketing status was read the same day from the FDA application record on Drugs@FDA, which is the only source that carries it.
This is general information, not medical advice. Every product on this page is prescription-only. Which one is right for you, at which strength, is a decision for you and a licensed clinician.
What are the brand names for estradiol?
Estradiol is sold in the United States under 24 FDA-approved names across 6 delivery forms, including the patches Climara, Vivelle-Dot, Minivelle, Menostar, Dotti and Lyllana, the gels EstroGel, Elestrin and Divigel, the spray Evamist, the vaginal products Estrace Cream, Vagifem, Yuvafem, Imvexxy, Estring and Femring, and the injections Delestrogen and Depo-Estradiol. Each brand is the same estradiol molecule packaged into a different delivery system, and the delivery system is what sets the strength, the dosing interval and how much of the hormone reaches general circulation. Two products carrying the same molecule can hold different FDA-approved indications: the Minivelle label covers hot flashes and osteoporosis prevention, while the Vivelle-Dot label covers those plus vaginal atrophy and hypoestrogenism.
A brand name being familiar does not mean the product is still sold. Estrace tablets are Discontinued at 0.5 mg, 1 mg and 2 mg on the FDA application record, and oral estradiol now reaches patients as a generic tablet. Compounded estradiol is a separate category with no FDA approval and no labelled strength to check against. What bioidentical actually means.
Every estradiol brand, with its labelled strengths
Grouped by delivery form. Every strength and every starting-dose quote comes from that product's own structured label on DailyMed, and every application number links the FDA record that carries its marketing status. Combination products with a progestogen are further down on their own, because mixing them into this table would make the estradiol strengths look comparable when they are not.
Patches
6 named products · 7 of 13 platforms we verify publish this form
Climara
estradiol transdermal system- Labelled strengths
- 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.06 mg/day, 0.075 mg/day, 0.1 mg/day
- How often
- Once weekly
- FDA application
- NDA 020375 (Bayer HealthCare)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start therapy with Climara 0.025 mg per day applied to the skin once weekly.”
The only branded estradiol patch carrying a 0.06 mg/day strength. Every other branded patch stops at five strengths; Climara has six. Two unbranded generic estradiol transdermal systems, ANDA 202985 and ANDA 075182, also carry 0.06 mg/day, so the strength itself is not exclusive to the brand.
Label on DailyMed (SPL effective 2026-03-26, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section. Therapeutic equivalence: AB2 on every strength, so a substitutable generic exists.
Vivelle-Dot
estradiol transdermal system- Labelled strengths
- 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, 0.1 mg/day
- How often
- Twice weekly
- FDA application
- NDA 020538 (Sandoz)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start therapy with Vivelle-Dot 0.0375 mg/day applied to the skin twice weekly.”
The application also carries four unbranded estradiol transdermal strengths, all Discontinued. The Vivelle-Dot strengths themselves are all marketed.
Label on DailyMed (SPL effective 2023-11-17, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section. Therapeutic equivalence: AB1 on every strength.
Minivelle
estradiol transdermal system- Labelled strengths
- 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, 0.1 mg/day
- How often
- Twice weekly
- FDA application
- NDA 203752 (Noven)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start therapy with MINIVELLE 0.0375 mg per day applied to the skin twice weekly.”
Same five strengths as Vivelle-Dot and two labelled indications rather than four. Vaginal atrophy and hypoestrogenism are not on this label.
Label on DailyMed (SPL effective 2026-07-31, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section. Therapeutic equivalence: AB3 on every strength.
Menostar
estradiol transdermal system- Labelled strengths
- 14 mcg/day
- How often
- Once weekly
- FDA application
- NDA 020375 (Bayer HealthCare)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Apply Menostar 14 mcg per day to a clean dry area of the lower abdomen once weekly.”
The lowest-dose estradiol patch approved in the United States, and the only product on this page with one indication that is not a symptom. Hot flashes are not on the Menostar label. It sits on the same application as Climara.
Label on DailyMed (SPL effective 2026-03-12, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section.
Dotti
estradiol transdermal system, USP- Labelled strengths
- 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, 0.1 mg/day
- How often
- Twice weekly
- FDA application
- ANDA 211293 (Amneal)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start therapy with DOTTI 0.0375 mg/day applied to the skin twice weekly.”
A generic wearing a brand name. The FDA application record lists the drug name as ESTRADIOL, not as Dotti, and the approval is an abbreviated application rather than a new one.
Label on DailyMed (SPL effective 2024-05-14, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section. Therapeutic equivalence: AB1, which is the code Vivelle-Dot carries.
Lyllana
estradiol transdermal system, USP- Labelled strengths
- 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, 0.1 mg/day
- How often
- Twice weekly
- FDA application
- ANDA 211396 (Amneal)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start therapy with LYLLANA 0.0375 mg per day applied to the skin twice weekly.”
Amneal's second branded generic patch, and it is not interchangeable with the first. Dotti is rated AB1 and Lyllana AB3, so they are equivalent to different reference products and carry different indication sets.
Label on DailyMed (SPL effective 2024-05-15, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section. Therapeutic equivalence: AB3, which is the code Minivelle carries.
Platforms on our roster publishing an estradiol patch: Alloy, Winona, Sesame Care, Hers Menopause, Wisp, Gala Health, Telos RX. Most publish the form and leave the manufacturer to the pharmacy. The 2 that name a product by name are listed further down. Prices by form.
Gels
3 named products · 3 of 13 platforms we verify publish this form
EstroGel 0.06%
estradiol gel, metered- Labelled strengths
- 1 pump depression delivers 1.25 g of gel containing 0.75 mg estradiol
- How often
- Once daily, applied to the arm
- FDA application
- NDA 021166 (Ascend Therapeutics US)
- Marketing status
- Marketed, except 0.06% topical gel, the non-metered presentation, which the record has as Discontinued
Starting dose, the label's own words
“EstroGel 0.06% 1.25 g per day is the single approved dose for the treatment of moderate to severe vasomotor symptoms due to menopause. The lowest effective dose of EstroGel 0.06% for this indication has not been determined.”
One approved dose and no titration ladder. The label says in its own words that the lowest effective dose has not been determined, which is unusual and worth knowing before a prescriber offers to lower it.
Label on DailyMed (SPL effective 2026-05-29, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section.
Elestrin
estradiol gel, metered- Labelled strengths
- 1 pump actuation delivers 0.87 g of gel providing 0.52 mg estradiol
- How often
- Once daily, applied to the upper arm
- FDA application
- NDA 021813 (Viatris Specialty)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start therapy with one pump per day (0.87 grams per day, which contains 0.52 mg of estradiol).”
The label states one starting dose and then says to adjust on clinical response without printing a ceiling. Each pump container is labelled for 30 metered doses.
Label on DailyMed (SPL effective 2023-12-15, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section.
Divigel 0.1%
estradiol gel- Labelled strengths
- 0.25 g packet (0.25 mg estradiol), 0.5 g packet (0.5 mg estradiol), 0.75 g packet (0.75 mg estradiol), 1.0 g packet (1.0 mg estradiol), 1.25 g packet (1.25 mg estradiol)
- How often
- Once daily, alternating upper thighs
- FDA application
- NDA 022038 (Vertical Pharmaceuticals)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start therapy with the 0.25 grams applied once daily on the skin of either the right or left upper thigh. Adjust the dose up to a maximum of 1.25 grams, as needed.”
Five packet strengths, the widest dose ladder of the three branded estradiol gels, and the only one of the three that prints an explicit maximum. Its five packet strengths are copied by several unbranded generic gels.
Label on DailyMed (SPL effective 2026-02-27, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section.
Platforms on our roster publishing an estradiol gel: Alloy, Sesame Care, Telos RX. Most publish the form and leave the manufacturer to the pharmacy. The 2 that name a product by name are listed further down. Prices by form.
Sprays
1 named product · 1 of 13 platforms we verify publish this form
Evamist
estradiol transdermal spray- Labelled strengths
- One spray of 90 mcL contains 1.53 mg estradiol
- How often
- Once daily each morning, to the inner forearm
- FDA application
- NDA 022014 (Padagis US)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start Evamist therapy with one spray of Evamist per day.”
The only approved estradiol spray. The dose is titrated by spray count rather than by strength: the label allows one, two or three sprays each morning to adjacent non-overlapping areas of the forearm.
Label on DailyMed (SPL effective 2024-10-29, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section.
Platforms on our roster publishing an estradiol spray: Alloy. Most publish the form and leave the manufacturer to the pharmacy. The 2 that name a product by name are listed further down. Prices by form.
Pills and capsules
1 named product · 5 of 13 platforms we verify publish this form
Estradiol Tablets, USP
estradiol- Labelled strengths
- 0.5 mg, 1 mg, 2 mg
- How often
- Once daily, administered cyclically (for example 3 weeks on and 1 week off)
- FDA application
- ANDA 040197 (Barr Labs)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“The usual initial dosage range is 1 to 2 mg daily of estradiol adjusted as necessary to control presenting symptoms.”
The widest indication set of any product on this page, and there is no brand-name version of it left. Estrace tablets, the brand these generics were approved against, are Discontinued at all three strengths.
Label on DailyMed (SPL effective 2024-02-01, read 2026-08-16 from the structured XML). Strengths from the Description and How Supplied section.
Platforms on our roster publishing an estradiol pill or capsule: Alloy, Winona, Hers Menopause, Gala Health, Telos RX. Most publish the form and leave the manufacturer to the pharmacy. The 2 that name a product by name are listed further down. Prices by form.
Vaginal products
6 named products · 5 of 13 platforms we verify publish this form
Estrace Cream
estradiol vaginal cream USP 0.01%- Labelled strengths
- 0.01% cream, each gram contains 0.1 mg estradiol
- How often
- Daily at first, then tapered to a maintenance dose
- FDA application
- ANDA 086069 (AbbVie)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“The usual dosage range is 2 to 4 g (marked on the applicator) daily for one or two weeks, then gradually reduced to one half initial dosage for a similar period. A maintenance dosage of 1 g, one to three times a week, may be used after restoration of the vaginal mucosa has been achieved.”
The only Estrace product still marketed. It is approved under an abbreviated application, not a new drug application, and the record lists it as both the reference listed drug and the reference standard.
Label on DailyMed (SPL effective 2024-05-29, read 2026-08-16 from the structured XML). Strengths from the Description section.
Vagifem
estradiol vaginal inserts- Labelled strengths
- 10 mcg insert (10.3 mcg estradiol hemihydrate equivalent to 10 mcg estradiol)
- How often
- Daily for 2 weeks, then twice weekly
- FDA application
- NDA 020908 (Novo Nordisk)
- Marketing status
- Marketed, except 25 mcg, which the record has as Discontinued
Starting dose, the label's own words
“Administer Vagifem intravaginally using the supplied applicator: 1 insert daily for 2 weeks, followed by 1 insert twice weekly.”
The 25 mcg insert that older guidance and older forum threads still refer to is Discontinued on the application record. Only the 10 mcg strength is marketed.
Label on DailyMed (SPL effective 2025-02-10, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section.
Yuvafem
estradiol vaginal inserts, USP- Labelled strengths
- 10 mcg insert (10.3 mcg estradiol hemihydrate equivalent to 10 mcg estradiol, USP)
- How often
- Daily for 2 weeks, then twice weekly
- FDA application
- ANDA 205256 (Amneal Pharms)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Administer Yuvafem intravaginally using the supplied applicator: 1 insert daily for 2 weeks, followed by 1 insert twice weekly.”
The generic of Vagifem 10 mcg, sold under its own brand name. Same strength, same schedule, same single indication.
Label on DailyMed (SPL effective 2024-04-03, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section. Therapeutic equivalence: AB, substitutable for Vagifem 10 mcg.
Imvexxy
estradiol vaginal inserts- Labelled strengths
- 4 mcg insert, 10 mcg insert
- How often
- Daily for 2 weeks, then twice weekly, every three to four days
- FDA application
- NDA 208564 (Mayne Pharma)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Generally, start therapy with the IMVEXXY 4 mcg dosage strength administered intravaginally.”
The only branded vaginal estradiol with a 4 mcg strength, which is the lowest labelled estradiol dose of any product on this page, and the only one on this page whose labelled indication is painful sex specifically rather than atrophy generally. An unbranded generic insert, ANDA 214137, carries the same 4 mcg and 10 mcg strengths.
Label on DailyMed (SPL effective 2025-09-16, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section.
Estring
estradiol vaginal system- Labelled strengths
- 2 mg ring releasing approximately 7.5 mcg of estradiol per day over 90 days
- How often
- One ring, worn continuously, replaced every 90 days
- FDA application
- NDA 020472 (Pfizer)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“One ESTRING is to be inserted as deeply as possible into the upper one-third of the vaginal vault. The ring is to remain in place continuously for three months.”
A local product. It is one of two estradiol vaginal rings and it is not the systemic one, which is the single most common mix-up in this category.
Label on DailyMed (SPL effective 2026-04-23, read 2026-08-16 from the structured XML). Strengths from the Description and How Supplied section.
Femring
estradiol acetate vaginal ring- Labelled strengths
- 0.05 mg/day (core contains 12.4 mg estradiol acetate), 0.10 mg/day (core contains 24.8 mg estradiol acetate)
- How often
- One ring, worn for 3 months
- FDA application
- NDA 021367 (Millicent)
- Marketing status
- All labelled strengths marketed
Starting dose, the label's own words
“Start therapy with 0.05 mg/day.”
A systemic dose delivered vaginally. It treats hot flashes, which Estring does not, and its daily delivery is roughly seven to thirteen times Estring's, calculated from the two labels. A woman prescribed a ring should know which of the two she is holding.
Label on DailyMed (SPL effective 2025-12-09, read 2026-08-16 from the structured XML). Strengths from the Dosage Forms and Strengths section.
Platforms on our roster publishing an estradiol vaginal product: Alloy, Winona, Hers Menopause, Wisp, Gala Health. Most publish the form and leave the manufacturer to the pharmacy. The 2 that name a product by name are listed further down. Prices by form.
Injections
2 named products · 0 of 13 platforms we verify publish this form
Delestrogen
estradiol valerate injection, USP- Labelled strengths
- 10 mg/mL, 20 mg/mL, 40 mg/mL
- How often
- Every four weeks for the menopause indications, intramuscular
- FDA application
- NDA 009402 (Par Health)
- Marketing status
- Marketed, except 40 mg/mL, which the record has as Discontinued
Starting dose, the label's own words
“The usual dosage is 10 to 20 mg DELESTROGEN every four weeks.”
The 40 mg/mL strength is Discontinued on the FDA record, and the current label still lists it under How Supplied with its own NDC and still gives handling instructions for it, warning that it provides a high concentration in a small volume. Elsewhere in the same section the label states that patients should be started at the lowest dose for the indication and that the lowest effective dose of DELESTROGEN has not been determined for any indication.
Label on DailyMed (SPL effective 2026-05-13, read 2026-08-16 from the structured XML). Strengths from the Description and How Supplied section.
Depo-Estradiol
estradiol cypionate injection- Labelled strengths
- 5 mg/mL
- How often
- Every 3 to 4 weeks, intramuscular
- FDA application
- ANDA 085470 (Pfizer)
- Marketing status
- Marketed, except 1 mg/mL and 3 mg/mL, which the record has as Discontinued
Starting dose, the label's own words
“The usual dosage range is 1 to 5 mg injected every 3 to 4 weeks.”
Two of its three approved strengths are Discontinued, so a 1 to 5 mg dose is drawn from a single 5 mg/mL vial. The vehicle is cottonseed oil and the preservative is chlorobutanol, which the label flags as possibly habit forming.
Label on DailyMed (SPL effective 2024-02-28, read 2026-08-16 from the structured XML). Strengths from the Description and How Supplied section.
No platform on our roster publishes an estradiol product in this form, which is worth knowing before you go looking for one online.
Which of these are actually still sold
A current label is not evidence that a product is on the market. The label describes what was approved; the application record says what is being shipped, and the two go out of step. Of the 24 products on this page, 5 carry at least one strength the FDA record lists as Discontinued. On 2 of them, Delestrogen and Activella, the current label still prints the retired strength and gives instructions for it.
The one that matters most
Estrace draws 9,900 searches a month in the United States, which ranks 2 of the 15 brand terms we sized (DataForSEO, 2026-08-16). The Estrace tablet is Discontinued at 0.5 mg, 1 mg and 2 mg across three separate abbreviated applications. Each carries a Federal Register determination that the product was not discontinued or withdrawn for safety or effectiveness reasons, which is the only reason the record rules out. It does not name the reason that applied, and we are not going to guess at one. The estradiol tablet itself is unaffected and remains available as a generic in the same three strengths. What is gone is the brand name.
| Product | What is discontinued | Record |
|---|---|---|
| Estrace tablets | All three oral strengths, 0.5 mg, 1 mg and 2 mgEach of the three carries a Federal Register determination that the product was not discontinued or withdrawn for safety or effectiveness reasons. The estradiol tablet itself remains widely available as a generic. | ANDA 081295, ANDA 084499 and ANDA 084500 |
| Vagifem | The 25 mcg vaginal tabletCarries the same Federal Register note. The 10 mcg insert remains marketed and is what the current label describes. | NDA 020908 |
| Delestrogen | The 40 mg/mL injectionCarries the same Federal Register note. The 10 mg/mL and 20 mg/mL strengths remain marketed. | NDA 009402 |
| Depo-Estradiol | The 1 mg/mL and 3 mg/mL injectionsOnly the 5 mg/mL concentration is still marketed. | ANDA 085470 |
| Activella | The 0.5 mg / 0.1 mg tabletCarries the same Federal Register note, and the current label still prints the strength and directs it for two indications. | NDA 020907 |
| EstroGel | The non-metered 0.06% topical gelThe metered pump presentation on the same application is the one marketed. | NDA 021166 |
| Vivelle-Dot | Four unbranded estradiol transdermal strengths on the same applicationAll five Vivelle-Dot strengths remain marketed. The Discontinued entries are the unbranded listings, not the brand. | NDA 020538 |
Marketing status read 2026-08-16 from the FDA application record, through the openFDA Drugs@FDA endpoint and confirmed against the human page linked in each row. Discontinued is a marketing status and not a safety finding; where the record carries the Federal Register determination, it is quoted above rather than paraphrased.
What each label is approved to treat, which is not the same product to product
This is the part that gets flattened everywhere else. Estradiol is described as a menopause hormone and left there, so two products get treated as swappable when their labels cover different conditions. Of the 19 estradiol-only products, 13 carry hot flashes as an approved indication and 6 do not. 5 of those 6 are local vaginal products, which is expected. The remaining one is a patch.
| Product | Approved for, in the label's own terms |
|---|---|
| ClimaraTransdermal patch |
|
| Vivelle-DotTransdermal patch |
|
| MinivelleTransdermal patch |
|
| MenostarTransdermal patch |
|
| DottiTransdermal patch |
|
| LyllanaTransdermal patch |
|
| EstroGel 0.06%Metered gel pump |
|
| ElestrinMetered gel pump |
|
| Divigel 0.1%Single-dose gel packet |
|
| EvamistTransdermal spray |
|
| Estradiol Tablets, USPOral tablet |
|
| Estrace CreamVaginal cream |
|
| VagifemVaginal insert |
|
| YuvafemVaginal insert |
|
| ImvexxyVaginal insert |
|
| EstringVaginal ring |
|
| FemringVaginal ring |
|
| DelestrogenIntramuscular injection |
|
| Depo-EstradiolIntramuscular injection |
|
The two rings, and why the difference is not cosmetic
Estring and Femring are both vaginal rings worn for three months, and they do different jobs. Estring holds 2 mg of estradiol and releases approximately 7.5 mcg a day, and its label covers vulvar and vaginal atrophy only. Femring contains estradiol acetate and delivers either 0.05 mg or 0.10 mg a day, and its label covers hot flashes as well. Femring's daily delivery is roughly seven to thirteen times Estring's, calculated from the two labels. A woman handed a ring for hot flashes needs the second one, and a woman who only wants local relief has no reason to take the systemic dose. Vaginal estrogen is priced and compared separately on our vaginal estrogen page.
Two more that are routinely mis-stated. Menostar is the lowest-dose patch at 14 mcg a day and its label carries one indication, prevention of postmenopausal osteoporosis, with hot flashes absent. Imvexxy is the only branded product here whose labelled indication is dyspareunia specifically, painful sex as a symptom of atrophy, rather than atrophy in general. Both distinctions decide whether a prescription is on-label.
Brand, generic, and the branded generics in between
Generic estradiol is the norm here rather than the exception. The openFDA National Drug Code directory, read 2026-08-16, lists oral estradiol tablet products from 38 distinct labelers, a count we calculated and one that includes repackagers as well as manufacturers. The FDA also prints a therapeutic equivalence code saying which generic substitutes for which brand, and reading that code answers questions the brand name cannot.
Two branded generics that are not equivalent to each other
Amneal sells estradiol patches under two names, Dotti and Lyllana. On the FDA record both are abbreviated applications and the drug name on both is ESTRADIOL rather than the brand. Dotti is coded AB1, the code Vivelle-Dot carries. Lyllana is coded AB3, the code Minivelle carries. They are equivalent to different reference products and their labels carry different indication sets, four on Dotti and two on Lyllana. Same company, same five strengths, and the FDA does not treat them as substitutes for each other.
An authorized generic and an abbreviated one
Activella has both. Lopreeza sits on the same application, NDA 020907, as an authorized generic, meaning it is the same product sold under a different name. Mimvey, under ANDA 079193, is a separate abbreviated approval and covers the 1 mg/0.5 mg strength only. Sesame Care names Mimvey in its published formulary, which is the level of detail almost no telehealth platform publishes.
A brand approved as a generic
Estrace Cream is approved under ANDA 086069, an abbreviated application rather than a new drug application, and the record lists it as both the reference listed drug and the reference standard for the products that copy it. It is the only estradiol product on this page where the brand everyone knows is itself the generic.
The oral tablet has no brand left
With Estrace tablets discontinued at every strength, estradiol on its own reaches patients by mouth only as a generic tablet at 0.5 mg, 1 mg or 2 mg. Bijuva, Activella and Angeliq are still branded and still swallowed, and all three carry a second hormone. That generic tablet label carries the widest indication set of any product on this page, six, including palliative use in metastatic breast cancer and in advanced prostate cancer, which is a reminder that estradiol is an older and broader drug than the menopause framing suggests.
The estradiol plus progestogen products
Every one of these labels says the same thing on the point, in close to the same words. The Activella label is indicated in a woman with a uterus, and the Delestrogen label states that when estrogen is prescribed for a postmenopausal woman with a uterus, progestin should also be initiated to reduce the risk of endometrial cancer. Our progesterone page prints the number from the Prometrium label that sizes that effect. These 5 products put both drugs in one delivery system. Which progestogen you get is the thing to check: only one of them uses progesterone itself.
Activella
estradiol with norethindrone acetate · Oral tablet · Once dailyLabelled strengths
1 mg estradiol / 0.5 mg norethindrone acetate · 0.5 mg estradiol / 0.1 mg norethindrone acetate
The clearest case on this page of a label and a marketing record disagreeing. The label prints two strengths and directs the lower one for two of the three indications; the application record has that strength as Discontinued. Lopreeza is the authorized generic on the same application, and Mimvey is a separate abbreviated approval of the 1 mg/0.5 mg strength only.
Label on DailyMed (SPL effective 2023-11-30) · NDA 020907. Discontinued on the record: 0.5 mg / 0.1 mg.
Angeliq
estradiol with drospirenone · Oral tablet · Once daily, continuous with no break between packsLabelled strengths
0.25 mg drospirenone / 0.5 mg estradiol · 0.5 mg drospirenone / 1 mg estradiol
The two strengths are not interchangeable across indications. For vaginal atrophy the label directs the 0.5 mg/1 mg tablet specifically.
Label on DailyMed (SPL effective 2026-03-02) · NDA 021355. All labelled strengths marketed.
Bijuva
estradiol with progesterone · Oral capsule · One capsule each evening with foodLabelled strengths
0.5 mg estradiol / 100 mg progesterone · 1 mg estradiol / 100 mg progesterone
The only FDA-approved product combining estradiol with progesterone itself rather than with a synthetic progestin. Every other combination on this page pairs estradiol with norethindrone acetate, drospirenone or levonorgestrel.
Label on DailyMed (SPL effective 2026-04-24) · NDA 210132. All labelled strengths marketed.
CombiPatch
estradiol with norethindrone acetate · Transdermal patch · Twice weekly, a new system every 3 to 4 daysLabelled strengths
0.05 mg estradiol / 0.14 mg norethindrone acetate per day (9 cm2 system) · 0.05 mg estradiol / 0.25 mg norethindrone acetate per day (16 cm2 system)
The estradiol dose is identical in both systems at 0.05 mg per day. What changes between them is the progestin, from 0.14 mg to 0.25 mg per day. A few lines after the starting-dose sentence the label adds that the lowest effective dose of CombiPatch has not been determined in clinical trials.
Label on DailyMed (SPL effective 2024-02-21) · NDA 020870. All labelled strengths marketed.
Climara Pro
estradiol with levonorgestrel · Transdermal patch · Once weeklyLabelled strengths
0.045 mg/day estradiol and 0.015 mg/day levonorgestrel
One strength only, so there is no dose to titrate. Its estradiol content of 0.045 mg per day does not match any single-strength Climara patch.
Label on DailyMed (SPL effective 2026-03-26) · NDA 021258. All labelled strengths marketed.
Bijuva is the only one pairing estradiol with progesterone, the molecule the ovary makes. The other four pair it with a synthetic progestin: norethindrone acetate in Activella and CombiPatch, drospirenone in Angeliq, levonorgestrel in Climara Pro. That distinction carries real weight in how people read the hormone therapy risk data, and what the evidence actually supports is narrower than either side of that argument tends to claim.
Which of these you can actually get from a telehealth platform
9 of the 13women's-wing platforms we price-verify dispense estradiol in some form, and they publish forms rather than products. Across every published formulary on our roster, only 5 of the brand names on this page appear at all: Evamist, Climara, Divigel, Estrace, Bijuva. The rest of the time you are told you will get an estradiol patch, and the manufacturer is settled at the pharmacy.
Alloy names Evamist
Evamist estradiol spray ($69.99/mo)
Sesame Care names Climara
Estradiol (generic Estrace, Climara, Divigel) [Verified July 2026]
Sesame Care names Divigel
Estradiol (generic Estrace, Climara, Divigel) [Verified July 2026]
Sesame Care names Estrace
Estradiol (generic Estrace, Climara, Divigel) [Verified July 2026]
Sesame Care names Bijuva
Estrogen-progestin (generic Prempro, Bijuva, Mimvey)
Read those strings closely and one of them is a small archaeology find. A platform offering “generic Estrace” is offering a generic of a tablet the FDA record lists as Discontinued at all three strengths. The generic is real and the drug is fine. The brand name in the description is doing work it can no longer back up, and the platform is describing its formulary the way the whole category still does.
What is not on this page, and why
- Oral contraceptives and the contraceptive patch and ring. They contain ethinyl estradiol, a different molecule from estradiol, and they are approved for contraception rather than for menopause.
- Premarin, Prempro and Duavee. Conjugated estrogens, not estradiol. Same drug class, different substance, so they cannot share a strength column with the products above.
- Myfembree. It does contain estradiol, and its approved indications are uterine fibroids and endometriosis rather than menopause, so a menopause table is the wrong place for it.
- Compounded estradiol. No FDA approval, no application record and no labelled strength to read. Several telehealth platforms dispense it and we say so on each provider review.
- Estrasorb and Prefest. Checked by name on DailyMed on 2026-08-16 and no current label was returned for either, and the FDA application record has both as Discontinued. Nothing about their strengths is publishable here.
- Alora, Vivelle and Amabelz. All three are listed as currently marketed on the FDA application record (Alora NDA 021310, Vivelle NDA 021167, Amabelz ANDA 203339) and none of them returned a current label on DailyMed on 2026-08-16. Without a label there is no strength, frequency or indication we can read, so they are named here rather than guessed at.
- Unbranded generics beyond the oral tablet. Dozens of estradiol patches, gels, creams, vaginal inserts and estradiol valerate injections are approved under their own abbreviated applications with no brand name. They are the same molecule in the same delivery forms as the products above. This page covers the named products plus the generic oral tablet, because the generic oral tablet is the only form where no brand is left to name.
FAQ
Estradiol brands, answered
What are the brand names for estradiol?
19 FDA-approved products carry estradiol or an estradiol ester as their only hormone and a brand name or an established name a patient can look up, and 5 more combine estradiol with a progestogen. By form: the patches are Climara, Vivelle-Dot, Minivelle, Menostar, Dotti and Lyllana; the gels are EstroGel, Elestrin and Divigel; the spray is Evamist; the pill is sold as generic estradiol tablets; the vaginal products are Estrace Cream, Vagifem, Yuvafem, Imvexxy, Estring and Femring; and the injections are Delestrogen and Depo-Estradiol. The combinations are Activella, Angeliq, Bijuva, CombiPatch and Climara Pro. Dozens of unbranded generics exist alongside these in the same delivery forms, approved under their own abbreviated applications, and they carry no brand name to look up. Brand names for the same molecule do not mean the same product: strengths, dosing schedules and approved indications differ from one to the next.
Is Estrace still available?
Estrace Cream is. Estrace tablets are not. The FDA application record lists Estrace tablets at 0.5 mg, 1 mg and 2 mg under three separate abbreviated applications, ANDA 081295, ANDA 084499 and ANDA 084500, and all three carry marketing status Discontinued along with a Federal Register determination that the product was not discontinued or withdrawn for safety or effectiveness reasons. Estrace Cream, the 0.01 percent vaginal cream under ANDA 086069, is still marketed. If you were prescribed an oral estradiol tablet and your pharmacy filled a generic, that is the whole market now: the brand it was approved against no longer ships.
What is the difference between Climara and Vivelle-Dot?
Frequency, strength count and starting dose. Climara is applied once weekly and Vivelle-Dot twice weekly. Climara is the only branded estradiol patch with a 0.06 mg/day strength, giving it six strengths against Vivelle-Dot's five, though two unbranded generic patches carry 0.06 mg/day too. The Climara label starts vasomotor treatment at 0.025 mg/day and the Vivelle-Dot label starts it at 0.0375 mg/day. Both labels carry the same four indications: hot flashes, vulvar and vaginal atrophy, hypoestrogenism, and prevention of postmenopausal osteoporosis. Minivelle, which looks like a Vivelle-Dot equivalent and shares its five strengths and twice-weekly schedule, carries only two of those four indications.
Which estradiol patch is the lowest dose?
Menostar, at 14 mcg per day, which is lower than the 0.025 mg per day (25 mcg) floor shared by Climara, Vivelle-Dot, Minivelle, Dotti and Lyllana. It is also the only patch here whose sole labelled indication is prevention of postmenopausal osteoporosis. Hot flashes are not on the Menostar label, so a prescription written for hot flashes is off-label. It sits on the same FDA application as Climara, NDA 020375.
Are Estring and Femring the same thing?
No, and this is the mix-up worth avoiding. Estring is a local product: a 2 mg ring releasing approximately 7.5 mcg of estradiol per day over 90 days, approved for moderate to severe symptoms of vulvar and vaginal atrophy. Femring contains estradiol acetate and delivers a systemic dose, either 0.05 mg or 0.10 mg per day for three months, and it is approved for hot flashes as well as atrophy. Both are rings worn for three months. Their daily estradiol delivery differs by roughly seven to thirteen times, calculated from the two labels, which is why one treats hot flashes and one does not.
Is generic estradiol as good as the brand?
For the products where a substitutable generic exists, the FDA says it is therapeutically equivalent and prints the code that says so. Climara carries AB2 on every strength, Vivelle-Dot AB1, Minivelle AB3, Estrace Cream AB, Vagifem's generic AB. The code matters more than the name: Amneal sells two branded generic patches, Dotti and Lyllana, and they are rated against different reference products, AB1 for Dotti and AB3 for Lyllana, so they are not interchangeable with each other. Two products can both be generic estradiol patches and still carry different labelled indications, which Dotti with four and Lyllana with two do.
Do telehealth platforms prescribe these brands?
Mostly they publish a form rather than a product. Of the 13 women's-wing platforms we price-verify, 9 dispense estradiol in some form, and only 5 of these brand names appear anywhere in their published formularies: Evamist, Climara, Divigel, Estrace, Bijuva. Everyone else lists "estradiol patch" or "estradiol pill" and leaves the manufacturer to the pharmacy. That is normal for a drug this thoroughly genericised, and it is worth knowing before you pick a platform because you wanted a specific product. Prices for each form are on our estradiol page. We publish no retail pharmacy price for any brand here, because we do not verify pharmacy pricing.
Related
- Estradiol, explained and then priced the molecule hub, with the price of every delivery form
- Vaginal estrogen, and why it is priced like a different drug covers Estrace Cream, Vagifem, Imvexxy and the rings
- Progesterone, and the number that explains why it is in your regimen
- The HRT dosage chart starting doses read off the same labels
- The estrogen patch guide and the patch shortage tracker
- Scored provider rankings and cheapest verified HRT
Sources
Two sources per product, both read 2026-08-16. Strengths, dosing and indications come from the structured label XML on DailyMed. Marketing status comes from the FDA application record, which is the only place it is published. www.fda.gov returns a 404 to automated clients, so no fda.gov press page is linked here; the FDA is named in prose and every hyperlink goes to DailyMed or to accessdata.fda.gov.
- Climara prescribing information, DailyMed and NDA 020375
- Vivelle-Dot prescribing information, DailyMed and NDA 020538
- Minivelle prescribing information, DailyMed and NDA 203752
- Menostar prescribing information, DailyMed and NDA 020375
- Dotti prescribing information, DailyMed and ANDA 211293
- Lyllana prescribing information, DailyMed and ANDA 211396
- EstroGel 0.06% prescribing information, DailyMed and NDA 021166
- Elestrin prescribing information, DailyMed and NDA 021813
- Divigel 0.1% prescribing information, DailyMed and NDA 022038
- Evamist prescribing information, DailyMed and NDA 022014
- Estradiol Tablets, USP prescribing information, DailyMed and ANDA 040197
- Estrace Cream prescribing information, DailyMed and ANDA 086069
- Vagifem prescribing information, DailyMed and NDA 020908
- Yuvafem prescribing information, DailyMed and ANDA 205256
- Imvexxy prescribing information, DailyMed and NDA 208564
- Estring prescribing information, DailyMed and NDA 020472
- Femring prescribing information, DailyMed and NDA 021367
- Delestrogen prescribing information, DailyMed and NDA 009402
- Depo-Estradiol prescribing information, DailyMed and ANDA 085470
- Activella prescribing information, DailyMed and NDA 020907
- Angeliq prescribing information, DailyMed and NDA 021355
- Bijuva prescribing information, DailyMed and NDA 210132
- CombiPatch prescribing information, DailyMed and NDA 020870
- Climara Pro prescribing information, DailyMed and NDA 021258
- ANDA 084499 and ANDA 081295, the other two Estrace tablet applications
- Keyword volumes and difficulty from DataForSEO Labs, United States, run 2026-08-16. The 15 brand terms sized come to 70,110 searches a month, calculated by summing the rows.
This is general information, not medical advice. Every product named here is a prescription medicine. Do not change a dose, a product or a schedule based on a table. Talk to a licensed clinician, and bring the specific product name with you, because as this page shows the name changes what the label allows. Reviewed by Iacob Pastina.
Midi Health
Sesame Care